Influence of physical exercise practice against SARS-CoV-2 (COVID-19) infection: narrative review

Gustavo José de Sá Pereira, Raphael do Santos Canciglieri, Célio Junior da Costa Fernandes, Leandro Pereira de Moura, Rodrigo Ferreira de Moura

Abstract


As a protective measure against the Covid-19 virus, the world health organization strongly recommended social isolation. Because of a lower offer of physical exercise, there was an increase in the number of physical inactivity, poor diet, and psychological disorders. In this sense, this literature review aims to address how the practice of physical exercise is important to protect the metabolic and psychological health of the population. During forced isolation, it was possible to observe an increase in sedentary lifestyle and poor diet. As an outcome, possible damage to the population's mental health was also identified. In contrast, it was observed that individuals who practiced physical exercise, managed to mitigate both metabolic and psychological damage. Ahead, it was also possible to observe that this practice significantly contributed to the individuals' immune system, which can collaborate with the organism in the fight against possible contamination. Given this, the objective of this review was to identify possible implications of physical exercise on psychological and immunological aspects in coping with Covid-19. Important physiological effects of exercise were found, such as elevation of the brain-derived neurotrophic factor (BDNF), which has beneficial effects in controlling depression and cognitive performance; the control of obesity through specific training methodologies can collaborate to control pro-inflammatory cytokines and increase mitochondrial function and immune system. In addition, there are up to 205 symptoms after infection by SARS-CoV2 and physical exercise can be a great ally for recovery. Therefore, it is believed that regular exercise has positive effects before, over, and post-pandemic.


Keywords


Covid-19; Depression; Health promotion; Exercise; Immune system.

Full Text:

PDF

References


Dong E DH, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Inf Dis 2021 [Available from: https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6.

Patrick G, Walker C, Oliver WJWCCfIDM, MRC Centre for Global Infectious Disease Analysis: Abdul Latif Jameel Institute for Disease, Emergency Analytics ICL. The global impact of COVID-19 and strategies for mitigation and suppression. 2020.

Jones NR, Qureshi ZU, Temple RJ, Larwood JPJ, Greenhalgh T, Bourouiba L. Two metres or one: what is the evidence for physical distancing in covid-19? 2020;370:m3223.

Ammar A, Brach M, Trabelsi K, Chtourou H, Boukhris O, Masmoudi L, et al. Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey. 2020;12(6):1583.

Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. The Lancet Neurology. 2020;19(9):767-83.

Reyes-Olavarría D, Latorre-Román PÁ, Guzmán-Guzmán IP, Jerez-Mayorga D, Caamaño-Navarrete F, Delgado-Floody P. Positive and Negative Changes in Food Habits, Physical Activity Patterns, and Weight Status during COVID-19 Confinement: Associated Factors in the Chilean Population. International Journal of Environmental Research & Public Health. 2020;17(15):5431.

Zhang Y, Sowers JR, Ren JJNRE. Targeting autophagy in obesity: from pathophysiology to management. 2018;14(6):356-76.

Mohamed AA, Alawna M. Role of increasing the aerobic capacity on improving the function of immune and respiratory systems in patients with coronavirus (COVID-19): A review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14(4):489-96.

Klempin F, Beis D, Mosienko V, Kempermann G, Bader M, Alenina N. Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis. The Journal of Neuroscience. 2013;33(19):8270.

López-Torres Hidalgo J. Effectiveness of physical exercise in the treatment of depression in older adults as an alternative to antidepressant drugs in primary care. BMC psychiatry. 2019;19(1):21.

Jia X, Yin C, Lu S, Chen Y, Liu Q, Bai J, et al. Two things about COVID-19 might need attention. 2020.

Sanchis-Gomar F, Lavie CJ, Mehra MR, Henry BM, Lippi G. Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide. Mayo Clinic Proceedings. 2020;95:1445+.

Rabi FA, Al Zoubi MS, Kasasbeh GA, Salameh DM, Al-Nasser AD. SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far. Pathogens (Basel, Switzerland). 2020;9(3).

Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). The Journal of pathology. 2020;251(3):228-48.

Pandey A, Patel KV, Lavie CJ, editors. Obesity, central adiposity, and fitness: understanding the obesity paradox in the context of other cardiometabolic parameters. Mayo Clinic Proceedings; 2018: Elsevier.

Cai Q, Chen F, Wang T, Luo F, Liu X, Wu Q, et al. Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. 2020;43(7):1392-8.

Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F, et al. Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission. Clin Infect Dis. 2020;71(15):896-7.

Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, Evaluation, and Treatment of Coronavirus (COVID-19). StatPearls. Treasure Island (FL): StatPearls Publishing

Copyright © 2021, StatPearls Publishing LLC.; 2021.

Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020;383(2):120-8.

Mauvais-Jarvis F. Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19. Diabetes. 2020;69(9):1857.

Yang X, Yu Y, Xu J, Shu H, Liu H, Wu Y, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. 2020;8(5):475-81.

López-Lluch G. Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity. Mechanisms of ageing and development. 2017;162:108-21.

Ørtenblad N. Mitochondrial increase in volume density with exercise training: More, larger or better? 2018;222(1):e12976.

Moreno Fernández-Ayala DJ, Navas P, López-Lluch G. Age-related mitochondrial dysfunction as a key factor in COVID-19 disease. Exp Gerontol. 2020;142:111147.

Heo J-W, Yoo S-Z, No M-H, Park D-H, Kang J-H, Kim T-W, et al. Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle. Int J Environ Res Public Health. 2018;15(10):2301.

Baumann FT, Zopf EM, Bloch W. Clinical exercise interventions in prostate cancer patients--a systematic review of randomized controlled trials. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2012;20(2):221-33.

Zimmer P, Jäger E, Bloch W, Zopf EM, Baumann FT. Influence of a six month endurance exercise program on the immune function of prostate cancer patients undergoing Antiandrogen- or Chemotherapy: design and rationale of the ProImmun study. BMC cancer. 2013;13:272.

Baumann FT, Zimmer P, Finkenberg K, Hallek M, Bloch W, Elter T. Influence of endurance exercise on the risk of pneumonia and Fever in leukemia and lymphoma patients undergoing high dose chemotherapy. A pilot study. Journal of sports science & medicine. 2012;11(4):638-42.

Murira A, Lamarre A. Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection. 2016;7(609).

Montgomery MK, Turner NJEc. Mitochondrial dysfunction and insulin resistance: an update. 2015;4(1):R1-R15.

Bhatraju NK, Agrawal A. Mitochondrial Dysfunction Linking Obesity and Asthma. 2017;14(Supplement_5):S368-S73.

Mohammadkhani R, Khaledi N, Rajabi H, Salehi I, Komaki AJPo. Influence of the maternal high-intensity-interval-training on the cardiac Sirt6 and lipid profile of the adult male offspring in rats. 2020;15(8):e0237148.

Saygin O, Karacabey K, Ozmerdivenli R, Zorba E, Ilhan F, Bulut V. Effect of chronic exercise on immunoglobin, complement and leukocyte types in volleyball players and athletes. Neuro endocrinology letters. 2006;27(1-2):271-6.

Karacabey K, Peker İ, Saygın Ö, Cıloglu F, Ozmerdivenli R, Bulut V. Effects of Acute Aerobic and Anaerobic Exercise on Humoral Immune Factors in Elite Athletes. Biotechnology & Biotechnological Equipment. 2005;19(1):175-80.

Zhang H, Tong TK, Kong Z, Shi Q, Liu Y, Nie JJSJoM, et al. Exercise training‐induced visceral fat loss in obese women: The role of training intensity and modality. 2021;31(1):30-43.

Safarimosavi S, Mohebbi H, Rohani H. High-Intensity Interval vs. Continuous Endurance Training: Preventive Effects on Hormonal Changes and Physiological Adaptations in Prediabetes Patients. J Strength Cond Res. 2021;35(3):731-8.

Codo AC, Davanzo GG, Monteiro LdB, de Souza GF, Muraro SP, Virgilio-da-Silva JV, et al. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis. Cell Metab. 2020;32(3):437-46.e5.

Dadgostar H, Firouzinezhad S, Ansari M, Younespour S, Mahmoudpour A, Khamseh MEJD, et al. Supervised group-exercise therapy versus home-based exercise therapy: Their effects on Quality of Life and cardiovascular risk factors in women with type 2 diabetes. 2016;10(2):S30-S6.

Besnier F, Gayda M, Nigam A, Juneau M, Bherer LJAopm, rehabilitation. Cardiac rehabilitation during quarantine in COVID-19 pandemic: challenges for center-based programs. 2020;101(10):1835-8.

Pedersen BKJNRE. Physical activity and muscle–brain crosstalk. 2019;15(7):383-92.

Moon Hyo Y, Becke A, Berron D, Becker B, Sah N, Benoni G, et al. Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Cell Metab. 2016;24(2):332-40.

Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, Yacoubi ME, et al. Alterations in 5-HT<sub>1B</sub> Receptor Function by p11 in Depression-Like States. Science. 2006;311(5757):77.

Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. 2014;159(1):33-45.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. 2012;481(7382):463-8.

Paolucci EM, Loukov D, Bowdish DME, Heisz JJ. Exercise reduces depression and inflammation but intensity matters. Biological Psychology. 2018;133:79-84.

Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re’em Y, et al. Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact. medRxiv. 2020:2020.12.24.20248802.

Toledo AC, Magalhaes RM, Hizume DC, Vieira RP, Biselli PJC, Moriya HT, et al. Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke. European Respiratory Journal. 2012;39(2):254.

Yamashina Y, Aoyama H, Hori H, Morita E, Sakagami N, Hirayama T, et al. Comparison of respiratory muscle strength in individuals performing continuous and noncontinuous walking exercises in water after the 6-week program. J Exerc Rehabil. 2019;15(4):566-70.

Kikuchi N, Mochizuki Y, Kozuma A, Inoguchi T, Saito M, Deguchi M, et al. Effect of online low-intensity exercise training on fitness and cardiovascular parameters. 2021.

Chastin SFM, Abaraogu U, Bourgois JG, Dall PM, Darnborough J, Duncan E, et al. Effects of Regular Physical Activity on the Immune System, Vaccination and Risk of Community-Acquired Infectious Disease in the General Population: Systematic Review and Meta-Analysis. Sports Med. 2021:1-14.




DOI: https://doi.org/10.23954/osj.v7i2.3118

Refbacks



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Open Science Journal (OSJ) is multidisciplinary Open Access journal. We accept scientifically rigorous research, regardless of novelty. OSJ broad scope provides a platform to publish original research in all areas of sciences, including interdisciplinary and replication studies as well as negative results.